Methods of Preparation of Live Attenuated Bacterial Vaccine by Alteration of Dna Adenine Methylase (dam) Activity in Those Bacteria

نویسندگان

  • Mark L. Lawrence
  • Daniel B. Paulsen
چکیده

U.S. Appl. No. 10/767,441, filed Jan. 30, 2004, Pending. U.S. Appl. No. 11/372,187, filed Mar. 10, 2006, Pending. Carter, "Observations on the Pathology and Bacteriology of Shipping Fever in Canada", Can. J. Comp. Med., vol. 18, No. 10, pp. 359-364, 1954. Collier, "Significance of Bacteria in Bovine Respiratory Disease", A.V.M.A., vol. 153, No. 12, pp. 1645-1651, 1968. Schiefer, et al., "Correlation of Microbiological and Histological Findings in Bovine Fibrinous Pneumonia", Vet. Pathol., vol. 15, pp. 313-321, 1978. Purdy, et al., "Serotyping and Enzyme Characterization of Pasteurella haemolytica and Pasteurella multocida Isolates Recovered from Pneumonic Lungs of Stressed Feeder Calves", Current Microbiology, vol. 34, pp. 244-249, 1997. Allen, et al., "The Microbial Flora of the Respiratory Tract in Feedlot Calves: Associations between Nasopharyngeal and Bronchoalveolar Lavage Cultures", Can, J. Vet. Res., vol. 55, pp. 341-346, 1991. Singer, et al., "Assessment of spatial and temporal clustering of ampicillinand tetracycline-resistant strains of Pasteurella multocida and P haemolytica isolated from cattle in California", JAVMA, vol. 212, No. 7, pp. 1001-1005, 1998. Gourlay, et al., "Experimental Pasteurella multocida pneumonia in calves", Res. Vet. Sci., vol. 47, pp. 185-189, 1989. Bryson, et al., "Observations on outbreaks of respiratory disease in housed calves-(1) Epidemiological, clinical and microbiological findings", Vet. Rec., vol. 103, pp. 485-489, 1978. Virtala, et al., "Epidemiologic and pathologic characteristics of respiratory tract disease in dairy heifers during the first three months of life", JAVMA, vol. 208, No. 12, pp. 2035-2042, 1996. Boyce, et al., "The Capsule is a Virulence Determinant in the Pathogenesis of Pasteurella multocida M1404 (B:2)", Infection and Immunity, vol. 68, No. 6, pp. 3463-3468, 2000. Rimier, et al., "Lipopolysaccharides of the Heddleston serotypes of Pasteurella multocida", Am. J. Vet. Res., vol. 45, No. 4, pp. 759-763, 1984. Brogden, et al., "Incubation of Pasteurella haemolytica and Pasteurella multocida lipopolysaccharide with sheep lung surfactant", Am. J. Vet. Res., vol. 47, No. 4, pp. 727-729, 1986. Confer, et al., "Intranasal vaccination of rabbits with Pasteurella multocida A:3 outer membranes that express iron-regulated proteins", AJVR, vol. 62, No. 5, pp. 697-703, 2001. Geschwend, et al., "Untersuchungen zu den Proteinen de auBeren Membran von Pasteurellen 2. Mittelilung; Eisenregulierte Proteine der auBeren Membran bei Pasteurella multocida und Pasteurella haemolytica", Berl. Munch Tierarztl Wschr, vol. 110, p. 386-390, 1997. Negrete-Abascal, et al., "Secretion of Proteases from Pasteurella multocida Isolates", Cuff. Micribiol., vol. 38, pp. 64-67, 1999. Straus, et al., "In Vivo Production of Neurarninidase by Pasteurella haemolytica in Market Stressed Cattle After Natural Infection", Current Microbiol., vol. 37, pp. 240-244, 1998. White, et al., "Extracellular Neuraminidase Production by a Pasteurella multocida A:3 Strain Associated with Bovine Pneumonia", Infection and Immunity, vol. 63, No. 5, pp. 1703-1709, 1995.

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Alteration of DNA adenine methylase (Dam) activity in Pasteurella multocida causes increased spontaneous mutation frequency and attenuation in mice.

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تاریخ انتشار 2012